Rimklb mutation causes male infertility in mice
نویسندگان
چکیده
منابع مشابه
Germline deletion of Cetn1 causes infertility in male mice.
Centrins are calmodulin-like Ca(2+)-binding proteins that can be found in all ciliated eukaryotic cells from yeast to mammals. Expressed in male germ cells and photoreceptors, centrin 1 (CETN1) resides in the photoreceptor transition zone and connecting cilium. To identify its function in mammals, we deleted Cetn1 by homologous recombination. Cetn1(-/-) mice were viable and showed no sign of re...
متن کاملGenetic Causes of Male Infertility
Infertility is a major health problem today, affecting about 15.0% of couples trying to have a child. Impaired fertility of the male is causative in 20.0% of infertile couples and contributory in up to another 30.0-40.0%. Infertility already affects about 5.0-7.0% of the general male population and may further increase in the future, considering the apparent trend of declining sperm count in in...
متن کاملMale Infertility and Its Causes in Human
Infertility is one of the most serious social problems facing advanced nations. In general, approximate half of all cases of infertility are caused by factors related to the male partner. To date, various treatments have been developed for male infertility and are steadily producing results. However, there is no effective treatment for patients with nonobstructive azoospermia, in which there is...
متن کاملCauses and Consequences of Male Infertility
Introduction: Infertility has various and innumerable causes, which pointing them out one by one is difficult and out of the scope of this paper. Infertility causes are different between males and females, and each case requires a separate and thorough research. The present study aimed to identify the male infertility causes. Methods: This study was conducted using a qualitative method, which ...
متن کامل[Causes and Factors of Male Infertility].
The preservation of reproductive health of the population is an important factor of demographic policy of the state. According to some authors from 14 to 30% of couples of reproductive age suffer from infertility, malefactor in such marriages is detected in more than half of the cases. As you know, in recent years there has been a significant deterioration in the main indicators of reproductive...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-84105-z